* Arcane Orb's pure damage ignores Mars' Bulwark.
* Astral Imprisonment can be used to stop Mars from being disruptive or save allies from his abilities.
* Sanity's Eclipse deals high damage to Mars, due to his low intelligence.

* Venomancer's poison attacks are all magical damage, ignoring Bulwark.
* Venomancer's multiple slows are especially effective against Mars' low mobility.
* Plague Wards can attack through Arena of Blood.
Additional:
* Venomancer's spells all deal magical damage, ignoring Bulwark.
* Venomancer's multiple slows are especially effective at kiting Mars.
* Plague Wards can attack through Arena Of Blood.

* Outworld Destroyer's pure and magical damage is particularly effective against Axe.
* Astral Imprisonment is an excellent way to defend against an initiating Axe.
* Sanity's Eclipse deals high damage to Axe due to his low mana pool.
Additional:
* Berserker's Call bonus armor doesn't block Arcane Orb's pure damage.
* Astral Imprisonment can be used to prevent an ally or Outworld Destroyer himself from an Axe initiation.
* Axe's low mana means he's susceptible to a powerful Sanity's Eclipse.

* Venomancer's slows and magical damage-over-time work well against Axe's complete lack of mobility.
* Plague Ward is especially useful for slowing down Axe, and revealing him before he initiates, as well as putting his Blink Dagger on cooldown.
Additional:
* Venomancer's slows and magical damage-over-time work well against Axe's complete lack of mobility.
* Plague Wards is especially useful for slowing down Axe, and revealing him before he initiates, as well as putting his Blink Dagger on cooldown.
* For the same reasons, Venomancer is a good ally for Axe when the situation is reversed.

* Outworld Destroyer's pure and magical damage is particularly effective against Earthshaker.
* Astral Imprisonment catches Earthshaker while he blinks in, preventing him from executing his combo.
* Earthshaker has mana troubles, and Outworld Destroyer's abilities can press this by stealing intelligence comes from Arcane Orb, therefore depleting his mana pool and mana regeneration.
* Sanity's Eclipse deals high damage to Earthshaker, due to his low intelligence and mana pool.

* Venomancer's slows and magical damage-over-time works well against Earthshaker's which completes lack of mobility.
* Plague Wards are useful for slowing and kitting down Earthshaker, revealing him from initiating and re-initiating and putting his Blink Dagger on cooldown if Venomancer has vision over Earthshaker.
Additional:
* Earthshaker can be kited by Venomancer's slows, which is lack of mobility.
* Plague Wards is very useful for slowing and kitting down Earthshaker, revealing him from initiating and re-initiating and putting his Blink Dagger on cooldown.

* In general, heroes that can slow down Dragon Knight's movement speed will do well against him. This includes Venomancer and others in addition to the heroes mentioned above.

* Arcane Orb's constant pure damage output is devastating to Dragon Knight.
* Dragon Knight's relatively low mana pool leads to heavy damage from Sanity's Eclipse, which also bypasses his armor.

* Shadow Demon, Outworld Destroyer and Tusk can all save a Lasso'd teammate with their defensive spells.

* Plague Wards are very hard for Batrider to play against as they provide a lot of vision as well as disable Blink Dagger for a long duration.

* Astral Imprisonment can be used to protect allies by imprisoning either them or Spirit Breaker.
* Arcane Orb will heavily drain Spirit Breaker's intelligence, rendering him almost useless and unable to cast spells. Spirit Breaker's low intelligence also means Sanity's Eclipse will deal a lot of damage to him.

* Heroes that can slow Charge of Darkness by a huge amount: Venomancer, Viper, Dazzle, Arc WardenLion

* Arcane Orb's pure damage penetrates Guardian Angel's defense.
* Astral Imprisonment's mana steal is devastating to Omniknight's already low mana pool.

* Heroes who can harass Omniknight out of lane will keep him weak in the mid game: Viper, Venomancer, Clinkz

* Tanky melee heroes that can easily be kited, which allows Outworld Destroyer to deal heavy damage with Arcane Orb from a distance: Sven, Underlord, Bristleback.

* Some heroes, such as Necrophos and Venomancer can be an issue if not initiated onto by Sven first.

* Untouchable won't mitigate Venomancer's magical damage, and Enchantress is vulnerable to magic damage.
* Both Venomous Gale and Poison Nova lowers the amount of healing received by Enchantress and her allies from Nature's Attendants.

* Arcane Orb's pure damage ignores Timbersaw's Reactive Armor.
* Astral Imprisonment, if timed correctly, can interrupt Timber Chain, preventing him from escaping.
Additional:
* Arcane Orb deals constant pure damage, which bypasses Timbersaw's Reactive Armor.
* Sanity's Eclipse can hit targets inside Astral Imprisonment, which helps Outworld Destroyer finish off Timbersaw before he escapes with Timber Chain. It can also drain his mana, limiting his ability to escape should he survive.

* Venomancer's magical damage-over-time poisons putting Tree Dance on cooldown, greatly diminishing Monkey King's mobility.
* Venomous Gale and Posion Nova will hit Monkey King when he is perched on a tree, or disguised by Mischief.
Additional:
* Venomancer's magical damage-over-time poisons will constantly put Tree Dance on cooldown, greatly diminishing Monkey King's mobility.
* Venomous Gale and Poison Nova will hit Monkey King when he is perched on a tree, or disguised with Mischief.
* However, Venomancer is also easily ganked by Monkey King if caught by surprise.

* Outworld Destroyer doesn't care if Razor steals his damage because he does most of his damage through Arcane Orb.
* Astral Imprisonment can prevent Razor from using the stolen damage from Static Link or chasing with Eye of the Storm.
* Sanity's Eclipse will do a ton of damage to Razor due to his low mana pool.

* Outworld Destroyer is not exceptionally dangerous to Necrohpos because of his Ghost Shroud, but his Astral Imprisonment can save his allies from Necrophos's Reaper's Scythe, though only if he uses it at the right time, If an Outworld Destroyer is nearby, Necrophos should not use Reaper's Scythe unless he has banished himself, or has banished two heroes within 15 seconds

* Astral Imprisonment can allow Outworld Destroyer to save himself or allies from Kunkka's full kit.
* Sanity's Eclipse deal a large amount of damage, as Kunkka's mana pool is much smaller than Outworld Destroyer's.
* Arcane Orb deals pure damage, shredding through Kunkka and his team even with Ghostship's buff.

* Arcane Orb deals pure damage, effectively bypassing Morphling's high armor from Attribute Shift (Agility Gain).
* Sanity's Eclipse is more effective against a low health and mana pool Morphling, enabling Outworld Destroyer to burst Morphling down before he can shift to Strength.
Additional:
* Arcane Orb deals high damage regardless of Morphling's high armor from Attribute Shift (Agility Gain).
* Because of Morphling's very low intelligence gain and base intelligence, Sanity's Eclipse will almost always be effective against Morphling.

* Unless Puck is facing the direction he wants to blink while in Phase Shift, the Venomous Gale and Poison Nova combo consistently ticks many times over several seconds, making it very difficult to use Blink Dagger towards the other direction. Puck's slow turning rate makes this even worse.

* Plague Wards may reveal a hiding Techies. If there's a sentry nearby, they may also reveal a stack of mines hidden in a juking spot.

* Astral Imprisonment protects an ally for much of Rolling Thunder's duration, especially at the lower levels. As Rolling Thunder has a considerable cast animation, an Outworld Destroyer with Blink Dagger can initiate on him and destroy his timing.

* Due to lack of magic resistance, Venomancer abilities eats through Windranger's health.
* Venomancer's multiple slows, to an extent, negates Windrun's mobility.
Additional:
* Due to lack of magic resistance, Venomancer poisons eats through Windranger's health.

* The pure damage provided by Arcane Orb is a great addition for killing Ember Spirit.
* Astral Imprisonment fully negates all magic damage of Flame Guard and Searing Chains and will temporarily save himself from Sleight of Fist's physical damage, and Ember Spirit is not a hero that can counter these skills.

* Outworld Destroyer's pure damage from Arcane Orb can go through Cold Embrace.
* Outworld Destroyer can negate the healing from Cold Embrace using Astral Imprisonment, and steal mana while doing so.
* Outworld Destroyer's damage during Winter's Curse is reduced due to Arcane Orb being unable to target allies.
Additional:
* Winter Wyvern must never put her allies in Cold Embrace against Outworld Destroyer as Arcane Orb will continue to deal damage to the defenseless hero.
* Arcane Orb does not hit his allies when he is taunted by Winter's Curse, making it weak against allies, but strong versus enemies.
* Astral Imprisonment can protect a target inflicted with Winter's Curse.

* Venomancer's poison damage-over-time are very effective against Spectre, which is lack of magic resistance from early to mid game.
* Venomancer's multiple slows greatly reduces Spectre's low mobility, even through Spectral Dagger.
* Plague Wards reveals Spectre while she is hiding on trees.
Additional:
* Venomancer's poison damage over time is very effective against Spectre, who tends to lack magic resistance during the early to mid game.
* Venomancer's multiple slows greatly reduces Spectre's movement speed and mobility.
* Plague Wards can scout out Spectre while she is hiding in trees.

* Sanity's Eclipse deals more damage the less max mana the heroes hit by it have, making Pudge an ideal target.
* Outworld Destroyer can save allies or himself caught by Dismember or Meat Hook with Astral Imprisonment.

* Venomancer can simultaneously scout Magnus hiding in trees and putting Blink Dagger on cooldown with Plague Wards, which makes Magnus real problems to blink and initiate.
Additional:
* Similar to Night Stalker, Venomancer can simultaneously scout Magnus hiding in trees and put Blink Dagger on cooldown with Plague Ward, which gives Magnus problems when trying to blink in and initiate.

* Venomancer's magical damage-over-time poisons greatly reduce Bounty Hunter's mobility.
* Venomous Gale, combined with Plague Wards and Poison Nova with True Sight items can allow Venomancer and his teammates to gank Bounty Hunter while he is roaming alone.

* Outworld Destroyer can steal more mana with Astral Imprisonment from Skywrath Mage with Shield of the Scion (granted by Aghanim's Shard). Shield of the Scion grants Skywrath Mage bonus intelligence every time he deals magic damage to an enemy hero with his abilities. The higher his intelligence, the larger his mana pool. Since Astral Imprisonment steals based on the target's max mana, Outworld Destroyer can steal much more mana from Skywrath Mage.

* Aggressively Poofing and Earthbinding is not going to end well against Venomancer, as he will be an easy target for Poison Nova.
* Venomancer's constant slows greatly reduce Meepo's mobility.

* Astral Imprisonment can save allies from a Black Hole combo. When upgraded with Aghanim's Scepter and Aghanim's Shard, it becomes exceedingly difficult to land good Black Hole against Outworld Destroyer's team.
* Astral Imprisonment can also cancel Black Hole while Enigma does not have Black King Bar.

* Arcane Orb deals heavy damage to both Lone Druid and the Spirit Bear.
* Astral Imprisonment can prevent the Spirit Bear from attacking, which is Lone Druid's main damage output.
* Sanity's Eclipse deals heavy damage to Lone Druid.

* Outworld Destroyer's pure damage will mop up Primal Split's units very quickly.

* Sanity's Eclipse will likely instantly kill all illusions.

* Venomous Gale, Poison Sting and Poison Nova deal damage over time and will chip away at Gravekeeper's Cloak in addition to slowing an already sluggish hero.
* Venomancer's normal attacks deal Poison Sting and will chip away at Gravekeeper's Cloak.

* Most Illusion based heroes (like Chaos Knight and Terrorblade) can't use their illusion beneficially against Sanity's Eclipse's high AoE burst damage.

* Primal Beast is mostly played in the offlane role, so picking a carry who can escape from him is essential. Heroes such as Troll Warlord, Lone Druid and Outworld Destroyer, or generally any carry with a stun, slow or ability to fight back will stop him from having the good start he needs.

* Any hero that can nullify effects of Chronosphere: (Keeper of the Light with Aghanim's Scepter during daytime, Winter Wyvern), banishing him or Faceless Void (Outworld Destroyer, Shadow Demon, Earth Spirit with Aghanim's Scepter) or protecting him in other ways (Dazzle, Oracle, Abaddon) can greatly limit Chronosphere's potential.

* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.

Additional:
* Outworld Destroyer's pure damage from Arcane Orb is very effective at killing Troll Warlord quickly.
* Astral Imprisonment removes Troll Warlord from a fight for four seconds, minimizing his contribution to a teamfight, and potentially wasting over half of Battle Trance's duration.
* Troll Warlord gains a measly 1 intelligence point per level, meaning Sanity's Eclipse is especially effective, often instantly killing him.

* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Destroyer.

* Due to her slow movement speed,heroes with crowd control and slows can shut down Dawnbreaker. ( Lion, Crystal Maiden ,Venomancer etc.)

* Ursa struggles against heroes with strong (and especially undispellable) disables (Disruptor, Puck, Shadow Demon, Outworld Destroyer and etc).

* Astral Imprisonment allows Outworld Destroyer to save himself or ally from Invoker's combo, or remove Invoker from a fight temporarily.
* Arcane Orb's pure damage will deal a lot of damage against Invoker's mediocre strength gain.
* EMP is useless against Outworld Destroyer by activating Equilibrium.
* However, be aware that Sanity's Eclipse will most likely not deal any damage at all, due to Invoker's high intelligence gain compared to Outworld Destroyer's.

* Astral Imprisonment allows Outworld Destroyer to save himself or his teamates during Omnislash.
* Juggernaut's low mana from his low intelligence gain means that he'll take a lot of damage from Sanity's Eclipse.

* Venomancer's damage over time can force Chen to use Hand of God prematurely, potentially wasting a chance to save his allies during a teamfight.

* Tanky melee heroes that can easily be kited, which allows Outworld Destroyer to deal heavy damage with Arcane Orb from a distance: Sven, Underlord, Bristleback.

Additional:
* Sanity's Eclipse only triggers Bristleback's passive once, and deals high damage against Bristleback's low intelligence.
* Outworld Destroyer's high burst damage is not negated by Bristleback's passive, So even if Bristleback turns his back on Outworld, Outworld Destroyer can decimate Bristleback quickly,
* If Bristleback attempts to flee, or tries to close the gap, Outworld can banish him with Astral Imprisonment, both reducing Bristlebacks much needed mana, and allowing Outworld to move in front of him, forcing him to take the full damage from his spells, This will also allow Outworld to land a devasting Sanity's Eclipse, without it being reduced by Bristleback's passive,

* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.

* Sanity's Eclipse does massive damage to Wraith King who naturally has a low mana pool and typically doesn't build items to increase it.
* Wraithfire Blast's slow projectile speed makes it easy to avoid using Astral Imprisonment.

* Heroes with mana burn: Nyx Assassin, Invoker, Outworld Destroyer, Pugna

* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.

* Heroes with hiding abilities can protect disabled allies: Outworld Destroyer, Shadow Demon, Tusk, Phoenix with Aghanim's Scepter.

* Astral Imprisonment is a versatile nuisance:
* If it is cast on a low-enough-health unit at least 1 second into Shallow Grave's duration, the Shallow Grave will end during the imprisonment, and the target will take lethal damage when released.
* It can be used remove Dazzle from the fight at a time he could have saved someone.
* It lets himself or an ally dodge all of Poison Touch's effects, for long enough to recover their Blink Dagger.

* Outworld Destroyer can save an ally hero caught by Duel with Astral Imprisonment, and he can inflict heavy damage on Legion Commander with Arcane Orb to aid his ally. However, if he gets caught, he is unlikely to survive the duel, due to his lack of durability.
Additional:
* Astral Imprisonment prevents Legion Commander from killing her opponents in Duels.

* Astral Imprisonment wastes Borrowed Time's duration.
* Outworld Destroyer's Sanity's Eclipse can kill Abaddon before Borrowed Time triggers due to the lack of intelligence for Abaddon.

* Arcane Orb's pure damage, making Counterspell ineffective.
* Sanity's Eclipse will hit Anti-Mage while he is disabled from Astral Imprisonment, and forces him to take heavy damage due to his low intelligence.
* Essence Flux keeps Outworld Destroyer at high mana, thus greatly reducing the damage from Mana Void.
Additional:
* Counterspell doesn't work versus Arcane Orb because it does pure damage.
* Anti-Mage cannot burn all of Outworld Destroyer's mana without disables due to Essence Flux.
* Anti-Mage's Manta Style illusions are quickly destroyed by Arcane Orb.
* However, if the enemy has multiple means of removing mana, Mana Void becomes a threat to Outworld Destroyer, Anti-Mage has better mobility than Outworld Destroyer with Blink, and Counterspell blocks a large portion of the damage from Sanity's Eclipse.

* Outworld Destroyer can disrupt Slark's attacks with Astral Imprisonment either by banishing Slark or his target.
* Slark's low heathpool means he will die quickly to Arcane Orb if he is directly attacked by Outworld Destroyer
* Slark has low intelligence gain, making him easy to finish with Sanity's Eclipse if he tries to run with Shadow Dance
Additional:
* Arcane Orb deals pure damage, which ignores the armor granted from permanent agility stacks.
* Astral Imprisonment can disrupt any Pounce attempt by banishing the leashed ally.
* Slark's low mana pool makes him more susceptible to Sanity's Eclipse.

* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.