* Pit of Malice can be cast in the path of Spirit Breaker's Charge of Darkness to cancel it.
* Dark Rift provides a way to escape from a gank for Underlord and his teammates.

* Dark Rift allows Underlord to transport allies from poison damage-over-time to the fountain.
* Underlord usually buys Pipe of Insight that gives a magic resistance to allies, inhibiting the damage from Venomancer abilities.

* Heroes with blink or movement abilities, which are disabled by Pounce's leash: Anti-Mage, Earth Spirit, Faceless Void, Magnus, Mirana, Monkey King, Morphling, Pangolier, Phantom Assassin, Phoenix, Puck, Queen of Pain, Riki, Sand King, Spirit Breaker, Timbersaw, Tusk.

* Dark Pact can dispel Venomous Gale and Poison Sting.
* Shadow Dance allows Slark heightened regeneration when out of vision making DoTs effects less threatening.

* Venomancer's damage-over-time abilities are easier to heal through with numerous Shadow Waves than other types of damage, and it's simple to time a Shallow Grave until the last possible second to save a teammate from them.

* Heroes that can slow Charge of Darkness by a huge amount: Venomancer, Viper, Dazzle, Arc WardenLion

* Corrosive Skin means Viper can often outlast Venomancer in a battle of attrition.
* Venomancer has no mobility without items, which makes him vulnerable to constant slows.

* Heroes that can slow Charge of Darkness by a huge amount: Venomancer, Viper, Dazzle, Arc WardenLion

* Durable heroes: Axe, Bristleback, Tidehunter, Wraith King

* While Reincarnation is off cooldown, Poison Nova poses less of a threat as Wraith King will return with all debuffs cleared.
* Vampiric Spirit can out-heal the slow {tooltip:DoT|Damage over Time} from Poison Sting.

* In the laning stage, making illusions of Venomancer will turn his Poison Sting back at him, making for an easy gank at level one, and for later when your mid comes for ganks.

* Heroes with ways to protect themselves or allies from Spirit Breaker's initiation: Shadow Demon

* Any hero that can outrange Plague Ward can neutralize them without putting themselves at risk of receiving Poison Sting: Arc Warden, Chen, Clinkz, Drow Ranger, Lina, Mirana, Nature's Prophet, Pugna and Sniper.
* Special mention to heroes that outrange Plague Ward after obtaining talents that increase attack range.

* Heroes that can slow Charge of Darkness by a huge amount: Venomancer, Viper, Dazzle, Arc WardenLion

* Heroes that usually builds Linken's Sphere as a core item: Weaver, Medusa, Morphling, Queen of Pain, Storm Spirit

* Squishy heroes or heroes without hard disables or silences: Shadow Demon, Shadow Fiend, Venomancer, Ancient Apparition etc.

* Due to Spirit Breaker's low attack speed, Tombstone is problematic for Spirit Breaker.
* The zombies summoned from Tombstone apply a stacking movement speed slow, which can significantly reduce Greater Bash's damage.
* Soul Rip and Decay allows Undying and his allies to survive from incoming ganks of Spirit Breaker.

* Borrowed Time & Aphotic Shield can dispel Venomous Gale and Poison Sting.

* Living Armor can mitigate a large portion of Spirit Breaker's damage since his attacks are slow.
* Treant Protector can also counter initiate Spirit Breaker with Leech Seed and his bash from Nature's Guise before he manages to escape.
Additional:
* Spirit Breaker's slow attacks cannot harm a hero shielded by Living Armor.

* Press the Attack dispels Venomous Gale and Poison Sting from Legion Commander or her teammates.
* Venomancer is an ideal target for Duel due to his lack of mobility and low starting health.

* Fortune's End can dispel Venomous Gale and Poison Sting from allies.
* Fate's Edict grants 100% magic resistance to target, inhibiting the damage from Venomancer abilities.

* Glimpse drags Spirit Breaker back from an escaping Charge, or takes him out of a ganking Charge.
* However, after purchasing Aghanim's Shard, a well-timed Nether Strike will completely nullify the Glimpse during a gank attempt.
* Static Storm can be used to instantly stop his charge if absolutely necessary, and also prevent a follow-up Nether Strike.

* Astral Imprisonment can be used to protect allies by imprisoning either them or Spirit Breaker.
* Arcane Orb will heavily drain Spirit Breaker's intelligence, rendering him almost useless and unable to cast spells. Spirit Breaker's low intelligence also means Sanity's Eclipse will deal a lot of damage to him.

* Venomancer is a low health hero and low range hero who is easy to harass with Ion Shell on a creep in the early game .
* Venomancer depends entirely on all his slows to keep distance or chase, but Surge ignores slows, so is nearly impossible to hunt or run away from Dark Seer or his surged teammates.

* Clockwerk can use Power Cogs to repel Spirit Breaker when he charges in with Charge of Darkness.
* Spirit Breaker's slow 0.6 second attack animation attacks do little damage against Clockwerk. It can also constantly be interrupted by Battery Assault.
* Nether Strike's 1.2 second charge time gives Clockwerk plenty of time to activate Blade Mail and for Battery Assault to cancel it.
Additional:
* Battery Assault will continuously prevent Spirit Breaker from using Nether Strike, Charge of Darkness and even right clicking because of his long attack animation.
* Charge of Darkness can be cancelled by a correctly timed Hookshot.
* Should Clockwerk or his allies be targeted by Charge of Darkness, he can stop it by casting Power Cogs in Spirit Breaker's path or around the target.

* Due to Spirit Breaker's low attack speed, Supernova is problematic for Spirit Breaker to take down, and even more so with Fire Spirits debuff applied.
* Icarus Dive grants Phoenix capability to quickly escape to safety.

* Snowball can be used to save allies or himself during Venomous Gale and Poison Nova.
* Venomancer lacks mobility and has low base health, so he can be killed by Walrus PUNCH!

* Voodoo Restoration heals to counter damage over time of Poison Nova and Poison Sting.

* Searing Chains can stop Charge of Darkness if timed correctly.
* Activate Fire Remnant can be used to escape an approaching Spirit Breaker, or lead Spirit Breaker into a bad situation.
* Activate Fire Remnant and Sleight of Fist allows Ember Spirit to dodge Charge of Darkness if timed correctly.

* Cold Snap allows Invoker to interrupt Charge of Darkness and Nether Strike.
* Tornado's long range can be used to cancel Charge of Darkness.
* Deafening Blast prevents Spirit Breaker from right clicking and thus proccing his Greater Bash.

* Bramble Maze stops Charge of Darkness in its tracks. Its very long duration means it can be used as an obstacle to block off an incoming Spirit Break during teamfights.
* Shadow Realm and Bedlam can be activated when Dark Willow sees Charge of Darkness coming, preventing Spirit Breaker from using Nether Strike after the initial stun.

* All of Venomancer's abilities are decent choices for Rubick's Spell Steal. Stealing Plague Wards makes them apply Poison Sting as well.

* Venomancer has low health, which makes him vulnerable to Lina's heavy magic damage.
* Fiery Soul attack speed bonus removes Plague Wards easily in all stages of the game.

* If Medusa activates Stone Gaze, the charge will inevitably fail.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation.

* Nether Strike can't remove Static Link and reduces Spirit Breaker's physical damage output.
* Eye of the Storm melts Spirit Breaker's armor, and makes him much less tanky.
Additional:
* Static Link drains damage bonus from Greater Bash, it cannot be removed by Nether Strike.
* Eye of the Storm melts Spirit Breaker's armor, and makes him much less tanky.

* Durable heroes: Axe, Bristleback, Tidehunter, Wraith King

* Enigma can be a perfect counter-initiator with his ultimate. A perfectly timed Black Hole will turn the tide of any initiation, especially from heroes like; Spirit Breaker, Legion Commander, Axe, Puck, and Slardar

Additional:
* Malefice prevents Spirit Breaker from using his spells for the duration.
* Demonic Conversion's eidolons have high magic resistance, receiving little damage from Charge of Darkness.

* Heroes who continue dealing damage while being stunned: Luna, Razor, Axe, Bristleback, Leshrac,

* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

* Slardar can attack through Plague Wards and gain Bash of the Deep charges, and Templar Assassin can spill Psi Blades through Plague Wards too.

* Heroes with mobility spells like Queen of Pain, Anti-Mage, Phantom Assassin, Riki, Puck, and Spirit Breaker that are cancelled by Frostbite can suffer greatly from the presence of Crystal Maiden. It is absolutely critical, however, to have followup from teammates, as all of the above heroes can make quick work of the squishy Crystal Maiden after they are released from her grip.

* Heroes that have a weak laning stage: Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, Omniknight, Pudge.

* Heroes who continue dealing damage while being stunned: Luna, Razor, Axe, Bristleback, Leshrac,

* Heroes that usually builds Linken's Sphere as a core item: Weaver, Medusa, Morphling, Queen of Pain, Storm Spirit

* Heroes with gap-closing abilities who attempt to use them for escaping Bloodseeker will suffer serious damage from Rupture: Phantom Assassin, Anti-Mage, Faceless Void, Riki, Slark, Spirit Breaker.

* Heroes that can cancel Charge of Darkness: Ogre Magi, Earthshaker, Lion .

* Heroes that usually builds Linken's Sphere as a core item: Weaver, Medusa, Morphling, Queen of Pain, Storm Spirit

* Mana Drain has an extremely long range and low cooldown. It can easily deplete most heroes of their entire mana pools, especially those with smaller mana pools such as Tiny or Spirit Breaker.

* Heroes that punish mobile heroes: Bloodseeker, Keeper of the Light

* Any hero that can outrange Plague Ward can neutralize them without putting themselves at risk of receiving Poison Sting: Arc Warden, Chen, Clinkz, Drow Ranger, Lina, Mirana, Nature's Prophet, Pugna and Sniper.
* Special mention to heroes that outrange Plague Ward after obtaining talents that increase attack range.

* Heroes with damage-over-time abilities will not only proc Bristleback's passive continuously, they will also do little harm to him when he is facing away from the source: Venomancer, Arc Warden

* Heroes who continue dealing damage while being stunned: Luna, Razor, Axe, Bristleback, Leshrac,

* In the early game, Omniknight can look like an easy target for Spirit Breaker, but with Purification and Degen Aura, what could be an opportunity could quickly turn into disaster.
* Heavenly Grace can be used to counter Charge of Darkness by minimizing the damage and lowering the stun duration with status resistance.
* Spirit Breaker's Greater Bash from all sources (Charge of Darkness or normal attacks) deals lesser damage if he is within the radius of Degen Aura.
* Due to this, Spirit Breaker's damage will always be lower when targeting Omniknight.

* Huskar can easily regenerate lost health from DoT spells through Berserker's Blood rendering them ineffective
* Venomancer has little armor and mobility, and rarely builds Linken's Sphere, so he is quite vulnerable to Life Break.

* Can easily interrupt and disable Spirit Breaker with hex if being charged.

* Solar Guardian can save an ally getting targeted and focused by Spirit Breaker

* Reflection illusion will apply Poison Sting back towards Venomancer.
* Conjure Image and Metamorphosis will make quick work of Plague Wards.
* While ticking down from Poison Nova, Terrorblade can wait until the last possible moment to Sunder a target, either friend or foe.

* Spirit Breaker's slow attack speed and moderate damage do very little to harm Dragon Knight, even if ganked with Charge of Darkness.