* Spectral Dagger and Haunt allow Spectre to get close to Lina.
* Desolate is very strong against Lina, who's usually a bit isolated in fights because of her high attack and cast range.
* Dispersion can mitigate a good portion of Lina's burst damage, allowing Spectre to turn on her afterwards.
Additional:
* Spectre can very easily close the distance on Lina with Haunt and Spectral Dagger, and due to Lina's abysmal mobility without a Blink Dagger and terrible health pool and armor, Lina easily gets slaughtered due Desolate.
* Dispersion can mitigate a good portion of Lina's burst damage, allowing Spectre to turn against her afterwards.

* Nethertoxin prevents buildup of Fiery Soul stacks.
* Corrosive Skin provides magic resistance against Lina's spells.
* Poison Attack and Viper Strike can burn away Lina's small health pool.

* Corrosive Skin minimizes the damage Viper takes from all of Ancient Apparition's abilities.
* Ancient Apparition's slow movement speed, squishy nature, and lack of escape abilities can easily be taken advantage of through Poison Attack and Viper Strike.

* As Ancient Apparition likes to stay far away from the fight to get full effectiveness from Ice Blast, he is a very good target for a Haunt gank.
* Ancient Apparition also has no hard disables and escape spells, making him an easy kill for Spectre.

* Haunt instantly allows her to get up and close with Sniper, and Spectral Dagger makes it difficult to escape from her.
* Spectre outcarries Sniper in the late game, so Sniper must try to end the game early before Spectre comes online.
Additional:
* Spectre can reach him easily in the backlines with Spectral Dagger or teleport to him with Haunt.
* He is usually a fair distance away from his allies, so Desolate will quickly tear Sniper down.
* Dispersion reflect or reduce his damage, making her hard to take down even at late game.

* Nethertoxin breaks Sniper's passives.
* Viper Strike together with Poison Attack can slow Sniper and tears through his low health and mobility.

* Most of Magnus' abilities except Empower will trigger damage through Corrosive Skin.
* Poison Attack and Viper Strike can slow Magnus during Skewer, as well as putting his Blink Dagger on cooldown, preventing him from initiating or re-initiating.

* Spectre can use Haunt to intercept and disrupt Magnus's initiation attempts.
* Spectral Dagger can severely slow down Magnus after he uses Skewer.
* Magnus often travels alone when he is trying to initiate, so Desolate can be very effective against him.
* In late game, Spectre can survive Reverse Polarity initiation thanks to Dispersion.
Additional:
* Spectre disables Magnus' Blink Dagger using her ultimate, and later into the game can usually outlive Reverse Polarity's duration.

* Spectre can instantly reveal Bounty Hunter's position on the activation of her ultimate Haunt. She can also semi-reveal( visible but not target-able) Bounty Hunter by hitting him with Spectral Dagger.

* Viper's poison abilities can slow Bounty Hunter's movement speed and allows to chase him with True Sight items.
* Nethertoxin can break Jinada, and the silence from level 25 prevents Bounty Hunter from using all of his spells.

* Poison Attack and Viper Strike allowing to kite and slow Earthshaker significally, putting Blink Dagger on cooldown and preventing him from initiating or re-initiating.
* Nethertoxin breaks Aftershock. The silence from Level 25 talent also prevents Earthshaker from initiating or re-initiating.
Additional:
* Being a melee hero, Earthshaker's movement is liable to suppression by Poison Attack and Viper Strike.
* Earthshaker's kit, with the exception of Enchant Totem, deals magic damage. Corrosive Skin effectively blunts his killing potential with a standard Blink combo among other things.
* Nethertoxin disables Aftershock, which removes the stun and bonus damage from Enchant Totem and Echo Slam.

* Spectral Dagger can be used to traverse past Fissure.
* Haunt will usually disable Earthshaker's Blink Dagger prior to a teamfight, preventing him from initiating.
* On the other hand, Haunt will amplify damage done from Echo Slam. Use this to your advantage.
Additional:
* Spectre can use Haunt to intercept and disrupt Earthshaker's initiation attempts.
* Spectral Dagger can be used to traverse past Fissure.
* Earthshaker often travels alone when he is trying to initiate, so Desolate can be very effective against him.
* Beware that the Haunt illusions amplify the damage done from Echo Slam, which can prove fatal for Spectre's own team.

* Hand of God has a long cooldown, so damage over time spells can be hazardous for Chen, forcing him to use it prematurely: Jakiro, Venomancer, Viper, Dazzle, Phoenix.

* Squishy heroes without good escape mechanism: Crystal Maiden, Chen.

* Nethertoxin disables Bristleback and prevents Warpath from building stacks. Besides losing his defensive passive, Bristleback also loses his ability to build up damage over lengthy battles.
* Viper can perpetually kite Bristleback with Poison Attack and Viper Strike.
Additional:
* Nethertoxin disables Bristleback's passive.
* Viper Strike and Poison Attack slow down Bristleback's movement speed so he's unable to get out from Nethertoxin.

* Nethertoxin prevents Timbersaw from gaining stacks on Reactive Armor.

* Black King Bar is useless for Phantom Assassin against Spectre, since all of the Spectre's abilities go through spell immunity,
* Blur cannot evade Desolate because its damage is a separate damage instance and is applied before the attack hits.
* Spectre's high durability provided by Dispersion and damage block items makes her one of the hardest carries to take down.
* Phantom Assassin has no way to stop Spectre from killing her allies.
Additional:
* Dispersion makes it hard for Phantom Assassin to burst down Spectre while also reflecting back Phantom Assassin's high burst damage against herself.
* Desolate ignores the evasion from Blur.
* Black King Bar is useless against Spectre as all of her skills pierce spell immunity.

* Heroes that can apply early pressure before Phantom Assassin has farm are massive threats: Axe, Viper, Meepo, Pugna, Slark etc.

* Dragon Knight is easily harassed by Poison Attack after the laning stage ends.
* Corrosive Skin protects Viper from Breathe Fire and returns damage.
* Nethertoxin mitigates Dragon Blood, Dragon's Knight main source of armor and health regeneration.
* Between Poison Attack and Viper Strike, Viper can keep Dragon Knight permanently slowed even in Elder Dragon Form.
Additional:
* In the early game, a Dragon Knight without Black King Bar is basically defenseless against Viper.
* Viper can harass Dragon Knight at any time with his Poison Attack.
* Corrosive Skin reduces damage from Dragon Fire and inflicts damage to him.
* Nethertoxin disables Dragon Blood, negating his main survivability.
* Viper Strike and Poison Attack can severely slow him down even with his Elder Dragon Form.

* Viper's Poison Attack and Viper Strike that can slow Razor, and is one of the few heroes that can keep him immobile.
* Altogether, Viper's skills reduce Razor's attack speed, heavily reducing the benefit of the damage drain from Static Link.
Additional:
* Storm Surge is counteracted by Nethertoxin, leaving Razor without faster MS.
* Static Link's damage drain doesn't bother Viper a lot as most of his early to mid game damage is magical.

* Corrosive Skin will protect Viper from Techies' magical damage.
* Even though Reactive Tazer will disarm Viper if he attacks Techies with Poison Attack, he does lots of damage with his other abilities that can still kill Techies.

* The damage over time from Viper's Poison Attack and Viper Strike rapidly wear down Refraction charges, allowing Templar Assassin to be damaged. Additionally, Corrosive Skin causes her attacks to apply damage overtime on her as well.
* Nethertoxin is a big threat to Templar Assassin. Her initially low range making it very hard to deal against Nethertoxin in the laning phase. At any stage of the game, a Nethertoxin can always force her to undo her Meld.
Additional:
* All of Viper's abilities quickly burn through Refraction charges.
* Templar Assassin's short range, aside from Psi Blades' spill damage, makes her vulnerable to Poison Attack harassment.
* Templar Assassin traditionally forgoes health and armor items for damage. Outside of Black King Bar, Viper will almost always be able to kill her when Refraction is down.

* Nethertoxin breaks Multicast.
* Corrosive Skin minimizes the damage from Ignite and Fireblast.

* Poison Attack and Viper Strike slows Axe significantly, and puts his Blink Dagger on cooldown, preventing him from initiating.
* Nethertoxin can break Counter Helix.
Additional:
* Nethertoxin prevents Counter Helix from triggering, which significantly lowers Axe's damage output in the early to mid game.
* Viper's various slows and damage over time prevents Axe from initiating as well as putting his Blink Dagger on cooldown.

* Nethertoxin breaks both Necromastery and Presence of the Dark Lord, reducing his damage massively.
* Corrosive Skin gives Viper bonus Magic Resistance against Shadowraze and Requiem of Souls.
* Viper can easily take advantage of Shadow Fiend's lack of escape and mobility spells with Viper Strike and Poison Attack. Poison Attack also serves as a great way to harass Shadow Fiend.

* Tiny has low movement speed and attack speed, making him vulnerable to Viper's slows.
* Corrosive Skin provides magic resistance to lower Tiny's magic burst damage.

* Corrosive Skin gives Viper additional resistance to Phoenix's magical damage, and since they deal damage over time, Phoenix would be constantly afflicted by his passive's own debuff, making him not an ideal target for Phoenix's harassment. Phoenix's abilities also constantly drain its own health away, becoming more vulnerable to Poison Attack.

* Zeus can deal a huge amount of damage, but he lacks defensive abilities, such as good mobility or resistance. Due to that, he doesn't like to be touched by any means. Heroes with higher damage output and good mobility will often get easily near Zeus and trade damage (eventually causing Zeus's downfall). Such Heroes include: Lycan, Slark, Storm Spirit, Spectre and others.

Additional:
* Zeus burst damage can be reduced by Dispersion and reflect some of the damage back to Zeus himself.
* Zeus has low mobility and stays in backlines, Spectral Dagger or Haunt can easily catch him as he has no escape mechanism.
* Since Zeus has low HP, Spectral Dagger and Desolate will quickly tear Zeus down when he's alone.

* Corrosive Skin counters Zeus in lane by canceling the effects of Clarity as Zeus relies on Arc Lightning to farm and secure last hits.
* Corrosive Skin also increases Viper's magic resistance to shrug off Zeus's magical nukes.
* Nethertoxin breaks Static Field.
* Due to Zeus' poor mobility, Viper Strike will cripple Zeus and will allow Viper and his teammates to land a lot of attacks.
Additional:
* Corrosive Skin severely reduces Zeus's damage output throughout the game.
* During the laning stage, Viper can abuse Zeus' reliance on spells by hugging the creep wave. Zeus will take constant damage over time from Corrosive Skin unless he drives Viper from the lane or returns to farming in his absence.
* Prior to buying Blink Dagger or Force Staff, Zeus is fragile and possesses low mobility. Any of Viper's numerous slows can set up an easy kill.

* Oracle's burst damage is not enough to take down Spectre due to Dispersion.
* Disarm from Fate's Edict does not hinder Spectre that much, since she can deal damage even without landing a single attack.
Additional:
* Oracle's burst damage is ineffective against Dispersion.
* Disarm provided by Fate's Edict is not as significant debilitation for Spectre as it might be for other carries since She can do damage even without landing attacks.

* As Crystal Maiden is squishy with very bad movement speed, Spectre can easily stay on Crystal Maiden with Haunt and Spectral Dagger.
* Late game, with enough farm, Spectre can withstand an entire Freezing Field, possibly even causing Crystal Maiden to kill herself from Dispersion.

* Heroes who can easily harass Crystal Maiden out of lane in the early game (Clinkz, Viper) can prevent Crystal Maiden from being able to level effectively, and can ultimately slow down her level 6, 12, and 18 to a point where enemy carries already have items to address her ultimate.

* Because Poison Attack has no cooldown, Aphotic Shield is ineffective as a hard dispel.
* Nethertoxin prevents Borrowed Time from activating passively and blocks Curse of Avernus

* Nethertoxin disables Vengeance Aura.
* Vengeful Spirit has no mobility spells aside from Nether Swap, which Viper can take advantage of with his slows.
* Viper can easily bully Vengeful Spirit out of a lane with Poison Attack.
Additional:
* Nethertoxin prevents the attack damage bonus from Vengeance Aura and the components of Nether Swap.
* Both Magic Missile and Wave of Terror are counteracted by Corrosive Skin, making Vengeful Spirit's fighting harder against Viper.

* Nethertoxin disables Berserker's Blood, which Huskar relies upon for attack speed and healing.
* The damage from Burning Spear and Life Break is largely absorbed by Corrosive Skin. It also will return some damage, making it risky to use Burning Spears in the laning stage.
* Because Huskar wants to be on low health for Berserker's Blood, he is particularly vulnerable to Poison Attack.
Additional:
* His Poison Attack is very useful against Huskar, since he tends to stay at low health.
* Nethertoxin disables passive skills like Berserker's Blood.
* It is dangerous for Huskar to jump on Viper because Corrosive Skin and Viper Strike with the slowdown of movement and attack speed which usually will be deadly for Huskar.

* Corrosive Skin minimizes the damage from Impale and Mana Burn.
* Nyx Assassin cannot survive several poison damage-over-time, even Spiked Carapace is activated.

* Nethertoxin breaks Fury Swipes, making Viper a decent counter to Ursa in a laning stage.
* Viper Strike is a strong, undispellable slow, making it much easier to kite Ursa for everyone.

* Spectre can easily close the distance on Drow Ranger with Haunt and stick on her with Spectral Dagger, effectively disables her Marksmanship.
* Spectre does not care if silenced by Gust, since Spectre will catch her up regardless.
* Dispersion can reflect some damage back to Drow Ranger should she chooses to attack.
* Be careful once she got her Silver Edge as an attempt to shut you down.

* Nethertoxin cancels out Kraken Shell and stops the hard dispel from passively activating, preventing Tidehunter from functioning as a frontline tank.
* Anchor Smash is mostly irrelevant against a ranged hero.
* Tidehunter relies on the threat of Ravage, which has an obscenely long cooldown. Viper can exploit the downtime with his short cooldowns.

* His global teleportation with Boots of Travel and Rearm is easily countered with Haunt, and Spectre can reach him anywhere on the map.
* He is squishy, and if alone Desolate will kill him very fast.
* Laser's blind isn't reliable, since Desolate cannot miss. Even worse, Dispersion can reflect and reduce his burst damage.

* Viper's Nethertoxin disables Cloak and Dagger, negating Riki's invisibility and much of his damage. It also makes him more vulnerable to magic damage, which does not go well with Riki's low health pool. With the talent applied, he can't even blink to safety or hide with Tricks of the Trade.
* Corrosive Skin makes it hard for Riki to chase Viper and attack him due to the attack speed slow.
* Viper Strike stays on Riki even after he goes invisible.
* Poison Attack makes it risky for Riki to get last hits and can make the laning phase difficult for him.

* Spectral Dagger follows Riki even after he goes invisible and stays on him through Tricks of the Trade, revealing his location.
* Desolate grants Spectre the ability to damage Riki with right clicks regardless of Smoke Screen's blind.
* Riki relies on his high damage to kill is opponents, which is countered by Dispersion.
* Haunt can find Riki globally at any time, negating much of his ganking potential.

* Heroes with break can disable Untouchable for a while: Doom and Shadow Demon (via Aghanim's Scepter), Viper, Shadow Shaman with Hex Breaks talent.

* Melee heroes with low mobility can be kited and killed by Viper: Treant Protector, Kunkka, Alchemist, Troll Warlord, Wraith King, Tiny, Sven.

* Enemies that possess high defenses through magic resistance, damage reduction, or high regeneration will make it difficult to whittle their health down to get to Reaper's Scythe's threshold. Such heroes include Bristleback (although only from behind), Spectre, Ursa, and Dragon Knight.

* Viper does large amounts of magic damage over time, meaning that if a Necrophos uses Ghost Shroud, Viper's abilities will greatly reduce Necrophos survivability, and may actually kill him.
* By the same token, Viper can use his Viper Strike on Necrophos if he attempts to heal himself with Ghost Shroud, and depending on any other effects Necrophos may have from him, (IE:Poison Attack,Corrosive Skin), Viper can often kill Necrophos while he is in his Ghost Shroud.
* Viper's Corrosive Skin helps him take reduced damage from all of Nercophos spells that deal magical damage, which is Necrophos's only source of damage.
Additional:
* Nethertoxin prevents Heartstopper Aura from dealing damage or healing Necrophos.
* Viper's magic damage is amplified whenever Ghost Shroud is used.
* Corrosive Skin makes Viper tankier against Death Pulse and Reaper's Scythe.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* Spectre can instantly escape Focus Fire or hunt a Windranger with Haunt.
* Spectre can catch up to her with Spectral Dagger, even if she uses Windrun.
* Desolate allows Spectre to hit Windranger through Windrun.
* Dispersion combined with Blade Mail and or Vanguard makes Spectre tanky and or also reflects some damage back to Windranger.
Additional:
* Spectre can catch up to her with Spectral Dagger, even if she uses Windrun.
* Spectre can instantly reach a ratting Windranger with Haunt.
* Windrun's miss chance is countered by Desolate.
* Dispersion can reflect some of her damage, especially from her Focus Fire.

* Since Windranger is bad against magical damage, heroes with continuous magical damage or magical nukes can blast her: Zeus, Tinker, Leshrac, Viper, Skywrath Mage, Lion, Lina, Venomancer.

* Heroes that can slow Charge of Darkness by a huge amount: Venomancer, Viper, Dazzle, Arc WardenLion

* Melee heroes with low mobility can be kited and killed by Viper: Treant Protector, Kunkka, Alchemist, Troll Warlord, Wraith King, Tiny, Sven.

* Spectre's entire ability set is designed to get to and destroy heroes that stay in the backlines, both carries (like the aforementioned Drow Ranger and Sniper) and supports (like Dazzle and Shadow Shaman).

* Melee heroes with low mobility can be kited and killed by Viper: Treant Protector, Kunkka, Alchemist, Troll Warlord, Wraith King, Tiny, Sven.

* Heroes with damage-increasing passive abilities, such as Viper and Riki, will usually kill Silencer in a short time before he even has time to set up his abilities.

* Shadow Step's low cooldown allows Spectre to teleport to him whenever he decides to push.
* Spectral Dagger allows Spectre to go through Sprout's trees and stun Nature's Prophet if she has a Skull Basher or Abyssal Blade.
* Spectre loves buying Radiance, which can kill Nature's Prophet's Treants easily.
Additional:
* Spectre can get to him anywhere on the map with Haunt.
* Spectre can pass through his trees with Spectral Dagger.
* Desolate's damage will melt him quickly, as he's alone most of the time.

* Poison Attack makes it hard for Void Spirit to lane against him.
* Corrosive Skin reduces the magical damage from Void Spirit's spells.

* Corrosive Skin minimizes the damage Viper takes from all of Disruptor's skills.

* Nethertoxin negates Essence Shift and the regeneration aspect of Shadow Dance.
* Dark Pact doesn't mean a lot against Viper's ubiquitous slows.
* Viper becomes a relevant presence in team fights before Slark can procure his standard items (e.g. Shadow Blade).

* Haunt can ruin Enigma's initiation with Blink Dagger, no matter where he is on the map.
* Spectre often buys Radiance, which allows her to deal damage over time to Enigma and put Blink Dagger on cooldown.
* Dispersion reflects the damage of Midnight Pulse and Black Hole inflicted back to Enigma. This can get even worse for Enigma if Spectre buys Blade Mail.
* All of Spectre's abilities ignore spell immunity, which means that even with Black King Bar, Enigma has absolutely little to no chance against Spectre at any stage of the game.

* Heroes that rely on evasion are slightly countered by Desolate: Phantom Assassin, Troll Warlord.

* Melee heroes with low mobility can be kited and killed by Viper: Treant Protector, Kunkka, Alchemist, Troll Warlord, Wraith King, Tiny, Sven.

* Nethertoxin prevents the buildup of Jingu Mastery stacks.
* Monkey King's high base movement speed is of little worth against the array of slows Viper possesses.
* All of Viper's magical damage over time stops Monkey King from using Tree Dance. It also ignores the extra armor bestowed by Wukong's Command.
Additional:
* Nethertoxin prevents the buildup of Jingu Mastery stacks.
* Viper's poison magical damage-over-time stops Monkey King from using Tree Dance. It also ignores the extra armor bestowed by Wukong's Command.

* The slow applied from Corrosive Skin offsets the movement speed bonus granted by Scorched Earth and the tick-based damage from Infernal Blade and Doom will continually slow Doom down. This allows Viper, much like Sniper, to 'kite' Doom and keep him at a safe distance between the two. Additionally, Corrosive Skin applies an attack-speed slow which is fairly crippling to a hero such as Doom that, naturally, has a high base attack-time, poor agility gain and builds little attack-speed items.
* Since Doom does not disable auto-cast abilities, Viper's Poison Attack will continue to work. Doom may find it hard to close the distance between himself and Viper, and thusly difficult to effectively lockdown and continually deal damage through his abilities.

* Nethertoxin disables Bulwark entirely, making Mars far less tanky. Using Nethertoxin inside Arena of Blood may discourage enemies from following up with Mars' initiation.
* Rod of Atos is currently common on Viper and keeps Mars in position long enough to be killed.
* Beware that Viper is not very tanky earlier in the game, so positioning against Mars is important since a well-timed Spear of Mars can be the end of Viper.
Additional:
* Nethertoxin breaks the damage block from Bulwark.
* Poison Attack and Viper Strike's slows make it difficult for Mars to contribute to fights due to his low mobility.

* None of Spectre's spells are very good for Rubick to Spell Steal.

* Corrosive Skin makes Viper receive less damage from Invoker's spells
* Viper can harass Invoker with his Poison Attack in the early game.
* Viper Strike and Poison Attack can kill Invoker easily if Ghost Walk is on cooldown.

* Nethertoxin disables Dawnbreaker's Luminosity|Dawnbreaker. Since she's a melee hero, she needs to close gap to attack and Nethertoxin will be bad for her since she cannot heal.
* Viper Strike and Poison Attack will severely slow her down and combined with Nethertoxin, it will be her death sentence (unless her Celestial Hammer or Solar Guardian are off cooldown). Besides that, chasing her down will be easy due to the slow.

* Corrosive Skin means Viper can often outlast Venomancer in a battle of attrition.
* Venomancer has no mobility without items, which makes him vulnerable to constant slows.

* Nethertoxin prevents the lifesteal from Ransack.
* Meepo and his clones have a lack of magic resistance, so they're vulnerable to Poison Attack & Viper Strike directed onto one clone.

* Nethertoxin cuts off Gravekeeper's Cloak, Visage's primary defense mechanism.
* Viper can ignore Grave Chill's attack speed slow with his magic damage output.
Additional:
* Since Visage is a slow hero, Viper can easily kite him with Poison Attack and Viper Strike while successfully chipping away at Gravekeeper's Cloak.
* Nethertoxin removes all layers of Gravekeeper's Cloak, leaving Visage exposed.
* Corrosive Skin makes Viper highly resistant to Soul Assumption.