* Heroes that have small health pools and little to no escape mechanisms are even easier prey for Necrophos. Ghost Shroud's slow will allow him to catch him with them, and get nuked down with his abilities, even preventing retaliation due to Reaper's Scythe's stun. Such heroes include Crystal Maiden, Witch Doctor, Warlock or Shadow Fiend.

* Reaper's Scythe can kill Alchemist before Chemical Rage has the time to heal him.
* Ghost Shroud can prevent Alchemist from attacking Necrophos, as well as make him immune to Acid Spray and Unstable Concoction damage.
* Heartstopper Aura will do damage as long as Necrophos is alive based on health percentage, which is a problem for a strength hero such as Alchemist.

* Ice Blast cancels out Chemical Rage's rapid health regeneration. It can also take advantage of Alchemist's Armlet of Mordiggian toggling, as it will make HP drain insanely fast, essentially killing the bearer in no time.
Additional:
* Ice Blast nullifies the health regeneration granted by Chemical Rage, which Alchemist greatly relies on to stay alive in battle.
* Alchemist tends to build Armlet of Mordiggian which can be deadly during Ice Blast.

* Heroes like Slark, Witch Doctor and others also tend to suffer in Ice Blast's heal denial.

* Tidebringer will deal lots of damage to Alchemist before he builds physical survivability items.
* Torrent and X Marks the Spot can control Alchemist at all stages of the game before he has Black King Bar.
* Ghostship's rum buff will greatly reduce the Alchemist's damage output in teamfights including his Radiance.

* Heroes with long channeling abilities like Witch Doctor are easy targets for Kunkka to interrupt in team fights.

* Visage can quickly kill heroes with low to medium base armor and no innate escape mechanism. Examples include Alchemist, Crystal Maiden and Zeus.

* Stone Form can easily interrupt heroes with long channeling spells, like Crystal Maiden, Bane, Witch Doctor, or Enigma.

* Heroes who rely on skills to become a heavy hitter in a certain amount of time can waste their timing because of a lucky Lucky Shot's disarm: Terrorblade, Sven, Clinkz, Windranger, Alchemist, Dragon Knight, Legion Commander

* Heroes who rely on channeling abilities can be interrupted in teamfights by Rolling Thunder: Crystal Maiden, Pugna, Witch Doctor

* Melee heroes that get kited easily have hard times dealing with Puck without any lockdowns, as Puck is one of the most mobile heroes. Heroes like Sven, Lifestealer, Ursa and Alchemist may have problems to get to Puck without proper initiation items. They also lack reliable lockdowns, as their disables are easily avoidable for Puck, or are just a soft disable.

* Low health spellcasters: Lina, Witch Doctor, Tinker, Keeper of the Light, all rely heavily on their spells and are fragile heroes. They all also have avoidable spells, allowing Puck to get to them and quickly burst them down.

* Vengeful Spirit has two abilities to interrupt Death Ward, even through Black King Bar.

* Without Dust of Appearance or Sentry Wards, Riki is able to silence Witch Doctor with Smoke Screen, and is likely to build a Diffusal Blade, leaving Witch Doctor without mana to cast Voodoo Restoration, as well as Skull Basher to interrupt Death Ward.

* Sacred Arrow can be used to interrupt Death Ward from a safe distance, forcing him to cancel it to dodge or get hit.
* Paralyzing Cask is a slow-moving stun, and Mirana can Leap away from her allies to keep it from bouncing.
* Witch Doctor has low health and can easily be killed with an Aghanim's Scepter combo or just when hit with an arrow.

* Wraithfire Blast cancels Death Ward in decent range.
* Death Ward is meaningless while Reincarnation is off cooldown.
* Vampiric Aura can out-heal the {tooltip:DoT|Damage over Time} from Maledict.

* Corrosive Haze followed by Slithereen Crush takes advantage of Alchemist's main weakness, being physical damage before he has the change to improve his surviability with items.
* Bash of the Deep will deal lots of damage during the laning phase.
Additional:
* Alchemist has a low starting armor and a low agility growth, which translates to a low armor growth . And since it is very uncommon for Alchemist to get straight to Assault Cuirass, or Shiva's Guard, Corrosive Haze makes him too vulnerable to physical damage, even with the hp regeneration of Chemical Rage

* It is especially easy for Oracle to negate the damage from Maledict, and even heal through it with Fate's Edict and Purifying Flames.
* If by some miracle an enemy is still about to die because of Maledict, he can still save him with False Promise.

* Beware of placing the Death Ward if Chronosphere is off cooldown, as it will cancel the effect and leave Witch Doctor vulnerable if he does not react in time.

* Skywrath Mage can easily harass Alchemist in the laning phase with multiple Arcane Bolts. Additionally, if Alchemist is in the process of throwing an Unstable Concoction, and has no way to dispel Ancient Seal, the self stun becomes an easy set up for Mystic Flare.
* Caution, however, as a decently farmed Alchemist with {Item ID:Radiance} and {Item ID:Manta Style} can easily send illusions to harass and force Skywrath Mage out.

* Kraken Shell dispels the stun from Paralyzing Cask. However, it does not dispel the damage from Maledict.
* Once Witch Doctor first uses his Death Ward in team fights, Tidehunter can simply cancel it with Ravage, turning the tables against him, especially if Witch Doctor does not have a Black King Bar.
* As a precaution, let Tidehunter use Ravage first before channeling Death Ward to turn a team fight in your favor.

* Lucent Beam interrupts Death Ward from a decent range.
* Eclipse kills Witch Doctor during Death Ward, even through Glimmer Cape.

* Guardian Angel protects allies from Death Ward's physical damage.
* Purification and Heavenly Grace will most likely save teammates from dying to Maledict.

* Alchemist's reliance on fast attack speed to do single-target damage makes him vulnerable to Static Link. It also goes through Black King Bar, which is a standard item on Alchemist.
* Eye of the Storm is great against high health strength heroes as it reduces their survivability to physical damage.
* Razor has early lane push to counter Acid Spray.

* Quas-Exort Invoker can win the mid lane easily against Alchemist because Quas regeneration will nullify Acid Spray's damage over time and Exort damage bonus will allow Invoker to out last hit Alchemist.

* Like any hero with a channeled spell, Last Word is a counter to it.
* Global Silence goes through spell immunity and prevents Witch Doctor from casting his spells.

* Every ability Witch Doctor has is useful when Rubick manages to steal any of them:
* Paralyzing Cask provides an additional disable apart from Telekinesis and also helps Rubick to farm.
* Voodoo Restoration provides utility by healing Rubick and his team, since he has no heal of his own.
* Maledict is a solid damage-over-time nuke, which can be devastating to the enemy team.
* And most importantly, Death Ward is one of the best teamfight spells in the game. It also requires channeling, which makes it easy for Rubick to steal. And when combined with Aghanim's Scepter, this can prove deadly to the enemy team.
* However, a skilled Witch Doctor will always toggle Voodoo Restoration while channeling Death Ward to prevent that.
Additional:
* Rubick can steal Death Ward easily as it is a channeled ability and then use it to turn teamfight to his advantage.
* However, a skilled Witch Doctor will toggle Voodoo Restoration immediately after placing his Death Ward to prevent that.

* Chemical Rage will rarely save Alchemist against Ursa's Fury Swipes.
* Enrage allows Ursa to both be a threat to Alchemist and avoid his over time damage.

* Death Ward does little damage against Dragon Knight's armor, and Dragon Knight's high health regeneration minimizes damage from Maledict.

* Shadow Dance allows Slark to not be targeted by Unstable Concoction, making Alchemist stun himself and making himself vulnerable to the enemy.
* Dark Pact also allows him to just purge off the stun if timed correctly.
* Essence Shift will steal stats over long durations at a time should Alchemist lack the damage to kill Slark.

* Feast is good against high health strength heroes such as Alchemist.
* Rage allows Lifestealer to not be targetable by Unstable Concoction, possibly making Alchemist stun himself.

* Morphling can Attribute Shift to strength after being hit by Maledict. Since Maledict deals its damage based on the difference between HP on cast and HP after two seconds, odds are Morphling will have more HP than when Maledict was cast, thus resulting in no damage.
* On the upside, players prone to panicked reactions may Morph to agility, making Maledict even more efficient than intended.
* Adaptive Strike (Strength) can interrupt Death Ward at a decent range.

* Ember's magic damage build is able to burst down Alchemist due to his low strength gain and Alchemist's normal item pick up.

* Untouchable greatly reduces Chemical Rage's attack speed advantage.

* Clinkz can use Burning Army in teamfights which will cause a problem for Alchemist.

* In general, melee heroes without blink mechanisms or spell immunity will have a hard time positioning against Pit of Malice: Sven, Tiny, Wraith King, Dragon Knight, Meepo, Doom, Bounty Hunter, Dark Seer, Undying, Alchemist, Legion Commander.

* Arc Warden's Magnetic Field dodges all damage from Death Ward. Should he choose to buy a Necronomicon, they are quite effective to absorb some shots from your cask, and attack you during Death Ward.

* Heroes that wish to disrupt fights with spell combos or big ultimates are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Devourer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Pugna's Decrepify makes sure that either Alchemist is unable to hit anyone while also being slowed and susceptible to magical damage, or can protect an ally from physical attacks. Besides, Pugna can push early on, when Alchemist is not strong enough to repel it, so by the time Alchemist comes online, he might be forced to sit in base.

* Low mobility heroes: Heroes with no/little means of traveling fast have difficulty getting to/away from Bounty Hunter due to his slowing Jinada and hastening Track. Few examples of such heroes are: Crystal Maiden, Sniper, Ursa, Witch Doctor, etc.

* Death Ward's first target (before it bounces) can evade it, therefore Windranger and Phantom Assassin are poor choices to use it on.
* However, once the first hit landed, the bounces can no longer miss. Don't forget to manually aim for a target with no evasion !

* Heroes with channeled abilities can be interrupted by a long-range Fissure: Crystal Maiden, Witch Doctor, Bane, Pugna, Pudge.

* Death Ward's first target (before it bounces) can evade it, therefore Windranger and Phantom Assassin are poor choices to use it on.
* However, once the first hit landed, the bounces can no longer miss. Don't forget to manually aim for a target with no evasion !

* Heroes who have channeled abilities can be stunned by Light Strike Array, like Witch Doctor with Death Ward and Bane's Fiend's Grip.

Additional:
* Light Strike Array cancels out Death Ward from a long distance.

* Heroes that have a channeled ability can be interrupted by Meat Hook: Pugna, Witch Doctor, Enigma, Bane.

Additional:
* Meat Hook interrupts Death Ward from a decent range, even through Black King Bar & Glimmer Cape.
* Pudge can survive the damage from Maledict because of his Flesh Heap stacks.
* However the damage-over-time from Rot is counteracted by Voodoo Restoration.

* Heroes with channeled abilities which Assassinate may cancel at long range: Witch Doctor, Crystal Maiden, Shadow Shaman, Pugna

* Heroes with powerful channeling abilities are easily interrupted by Phantom's Embrace: Bane, Pudge, Witch Doctor, Crystal Maiden, Enigma.

* Paralyzing Cask's short stun rarely prevents Monkey King from ambushing Witch Doctor.
* Death Ward's long channel is easily interrupted by Boundless Strike.

* Alchemist has very bad armor and does not build armor items for the large majority of his build, so Jingu Mastery and Wukong's Command can be very deadly.
* Desolator, Sange and Yasha or Diffusal Blade can all be purchased to increase your damage against Alchemist or just to keep your movement speed high enough to match him while Chemical Rage is active.
* Monkey King is an agility hero and scales with armor, so Acid Spray loses it's effectiveness later in the game.

* Heroes with plenty of summons, such as Broodmother or Nature's Prophet can have their minions soak up most of your Paralyzing Cask.

* Sprout is good for trapping melee carries with no escape abilities: Sven, Ursa, Alchemist, Lifestealer etc.