* Like any hero with a channeled spell, Last Word is a counter to it.
* Global Silence goes through spell immunity and prevents Witch Doctor from casting his spells.

* Arcane Curse stacks every time Bristleback uses an ability, forcing him to stop spamming his abilities, or take heavy health degeneration.
* Glaives of Wisdom steals intelligence both permanently and temporarily, causing mana issues for Bristleback .
* Last Word and Global Silence stops Bristleback from using his abilities altogether.
Additional:
* Bristleback will not be able to cast Viscous Nasal Goo or Quill Spray while silenced, effectively blocking a major part of the hero's damage and preventing Warpath charges from stacking.
* Arcane Curse slows Bristleback down and lasts longer the more abilities he uses. On the other hand, if he doesn't use any abilitiess, he will begin to lose Warpath charges.

* Time Dilation prevents Bristleback from spamming his low-cooldown abilities, greatly reducing his damage and effectiveness.
* Chronosphere allows allies to resposition and hit Bristleback from the front, bypassing his defensive bonus from behind.
* Bristleback has no way to prevent Faceless Void from using Time Walk.
Additional:
* Time Dilation while Quill Spray and Viscous Nasal Goo are on cooldown will make these abilities unusable for a long time, rendering Bristleback nearly useless.
* Bristleback cannot turn inside the Chronosphere, which makes it easy to attack him from the front, completely bypassing his passive damage reduction.

* Beware of placing the Death Ward if Chronosphere is off cooldown, as it will cancel the effect and leave Witch Doctor vulnerable if he does not react in time.

* Generally, any fragile heroes will have a hard time dealing with Undying's tankiness, and even more so if Decay is used on them. Some examples are Crystal Maiden and Witch Doctor.

* Undying's Decay is a dangerous ability against Bristleback, as it makes him more vulnerable and reduces his tankiness.
* Undying's Tombstone together with Flesh Golem can slow Bristleback down significantly.

* Witch Doctor's Maledict burst damage can be prevented by Sunder, if timed correctly.
* Death Ward deals physical damage, and Terrorblade's high armor can help him survive against Death Ward.
* However, be careful that Paralyzing Cask is commonly tricky to dodge as Terrorblade, due to his reliance of illusions, and Maledict can kill Terrorblade if he has no target to be Sundered with, especially in the early game.

* Terrorblade's Sunder is not affected by the Bristleback damage reduction.

* Heroes with powerful channeling abilities are easily interrupted by Phantom's Embrace: Bane, Pudge, Witch Doctor, Crystal Maiden, Enigma.

* Phantom's Embrace silences Viscous Nasal Goo and Quill Spray.
* Ink Swell stuns Bristleback and gets allies in position faster with increased movement speed to attack his front, countering his passive ability.

* Heroes like Slark, Witch Doctor and others also tend to suffer in Ice Blast's heal denial.

* Heroes that withstand damage like Timbersaw, Bristleback, Dragon Knight and others will have their durability largely reduced when hit by an Ice Blast due to the risk of shattering.

* Heroes with slow movement speeds and small health pools (supports like Crystal Maiden or Witch Doctor) are easy targets for Phoenix. Should they be inflicted by its DOT debuffs, they will be very quickly killed without even getting a chance to fight back.

* Heroes with high health especially Strength heroes will take more damage on Sun Ray: Axe, Pudge, Bristleback, Mars.

* Heroes who deal single instance burst damage will only proc Bristleback once: Lina, Lion.

* Heroes who have channeled abilities can be stunned by Light Strike Array, like Witch Doctor with Death Ward and Bane's Fiend's Grip.

Additional:
* Light Strike Array cancels out Death Ward from a long distance.

* Eye of the Storm melts Bristleback's armor, and makes him much less tanky.
* Static Link can completely drain Bristleback's bonus damage from Warpath.
Additional:
* Eye of the Storm melts Bristleback's armor, and makes him much less tanky.
* Static Link can completely drain Bristleback's bonus damage from Warpath.

* Sanity's Eclipse only triggers Bristleback's passive once, and deals high damage against Bristleback's low intelligence.

* Wraithfire Blast cancels Death Ward in decent range.
* Death Ward is meaningless while Reincarnation is off cooldown.
* Vampiric Aura can out-heal the {tooltip:DoT|Damage over Time} from Maledict.

* Sacred Arrow can be used to interrupt Death Ward from a safe distance, forcing him to cancel it to dodge or get hit.
* Paralyzing Cask is a slow-moving stun, and Mirana can Leap away from her allies to keep it from bouncing.
* Witch Doctor has low health and can easily be killed with an Aghanim's Scepter combo or just when hit with an arrow.

* Bristleback's tankiness doesn't help him very much against Fury Swipes in long teamfights.
* With no escape mechanism and a slow movement speed, getting jumped on by Ursa usually spell a quick end for Bristleback in the early game.

* Kraken Shell dispels the stun from Paralyzing Cask. However, it does not dispel the damage from Maledict.
* Once Witch Doctor first uses his Death Ward in team fights, Tidehunter can simply cancel it with Ravage, turning the tables against him, especially if Witch Doctor does not have a Black King Bar.
* As a precaution, let Tidehunter use Ravage first before channeling Death Ward to turn a team fight in your favor.

* Guardian Angel protects allies from Death Ward's physical damage.
* Purification and Heavenly Grace will most likely save teammates from dying to Maledict.

* Reaper's Scythe and Heartstopper Aura deal percentage-based damage, ignoring Bristleback's high health.
* Heartstopper Aura's HP removal does not trigger Bristleback's passive.
Additional:
* Heartstopper Aura deals percentage-based damage flagged as HP removal, so it is not reduced by Bristleback, nor does it trigger passive Quill Sprays.
* Reaper's Scythe is very effective against Bristleback not only due to its percentage-based damage, but rather because it first stuns and then deals its damage, allowing Necrophos to position in front of Bristleback in time.

* Heroes that have small health pools and little to no escape mechanisms are even easier prey for Necrophos. Ghost Shroud's slow will allow him to catch him with them, and get nuked down with his abilities, even preventing retaliation due to Reaper's Scythe's stun. Such heroes include Crystal Maiden, Witch Doctor, Warlock or Shadow Fiend.

* Mana Drain is a headache for Bristleback to deal with during the laning stage, as it denies him the ability to get last hits with Quill Spray.
* Finger of Death deals high damage to Bristleback, and only triggers his passive once.

* Shukuchi gets Weaver in front of Bristleback, negating the protection from the Bristleback passive.
* Weaver's mana break talent depletes Bristleback's mana pool, preventing him from spamming abilities.

* Bristleback's passive Bristleback can be disabled by Hoodwink's Sharpshooter ability for a long period of time

* Sinister Gaze forces Bristleback to face Lich, exposing him to damage.
* Lich's plethora of slows make it easy to kite Bristleback.

* Guardian Sprint allows Slardar to outrun Bristleback, even when slowed by Viscous Nasal Goo.
* Corrosive Haze's armor reduction makes Bristleback much less tanky.

* Whirling Death deals damage as well while reducing 15% of Bristleback's strength, which reduces Bristleback's tankiness.
* Reactive Armor can sustain through multiple Viscous Nasal Goo and Quill Spray stacks.
* Timber Chain makes it hard for Bristleback to slow down Timbersaw with Viscous Nasal Goo.

* Vengeful Spirit has two abilities to interrupt Death Ward, even through Black King Bar.

* Bristleback's reliance on physical damage with Quill Spray is negated by Bulwark.
* Mars can knock back Bristleback to prevent him from chasing down allies with Viscous Nasal Goo.

* Duel makes Bristleback fight Legion Commander face to face, forcing him to take full damage.
* Press the Attack dispels the slow from stacks of Viscous Nasal Goo.
Additional:
* When dueled, Bristleback will have to face Legion head on, not allowing his passive Bristleback to come into effect.

* Mana Break quickly eats away at Bristleback small mana pool, preventing him from spamming Viscous Nasal Goo and Quill Sprays.
* Bristleback has no innate mobility. Bristleback is easily kited by Blink, ignoring the protection from Bristleback.
Additional:
* Mana Break quickly depletes Bristleback's low mana, denying him the ability to spam Quill Spray and Viscous Nasal Goo.
* Bristleback has no way to prevent Anti-Mage from using Blink.

* Morphling can Attribute Shift to strength after being hit by Maledict. Since Maledict deals its damage based on the difference between HP on cast and HP after two seconds, odds are Morphling will have more HP than when Maledict was cast, thus resulting in no damage.
* On the upside, players prone to panicked reactions may Morph to agility, making Maledict even more efficient than intended.
* Adaptive Strike (Strength) can interrupt Death Ward at a decent range.

* Stone Form can easily interrupt heroes with long channeling spells, like Crystal Maiden, Bane, Witch Doctor, or Enigma.

* Heroes that wish to disrupt fights with spell combos or big ultimates are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Heroes with channeled abilities can be interrupted by a long-range Fissure: Crystal Maiden, Witch Doctor, Bane, Pugna, Pudge.

* Death Ward's first target (before it bounces) can evade it, therefore Windranger and Phantom Assassin are poor choices to use it on.
* However, once the first hit landed, the bounces can no longer miss. Don't forget to manually aim for a target with no evasion !

* Heroes who rely on channeling abilities can be interrupted in teamfights by Rolling Thunder: Crystal Maiden, Pugna, Witch Doctor

* Batrider's turn rate slow from Sticky Napalm makes it harder for Bristleback to keep his back towards the enemy.

* Heroes with channeled abilities which Assassinate may cancel at long range: Witch Doctor, Crystal Maiden, Shadow Shaman, Pugna

* Death Ward's first target (before it bounces) can evade it, therefore Windranger and Phantom Assassin are poor choices to use it on.
* However, once the first hit landed, the bounces can no longer miss. Don't forget to manually aim for a target with no evasion !

* Heroes with long channeling abilities like Witch Doctor are easy targets for Kunkka to interrupt in team fights.

Additional:
* Torrent can cancel Death Ward from a far distance.

* Infernal Blade deals scaling damage and is useful against high health targets such as Bristleback.
* Doom disables Bristleback's low cooldown abilities, preventing him from triggering Warpath. With Aghanim's Scepter, it also breaks Bristleback's passive, rendering him more vulnerable.
Additional:
* Infernal Blade deals scaling damage and is useful against high HP targets such as Bristleback.
* If Doom gets an Aghanim's Scepter, he can disable Bristleback, taking away much of his durability.
* Doom prevents Bristleback from casting his two low cooldown abilities, which then prevents him from utilizing Warpath.