* Riki is a natural Diffusal Blade carrier, and it doesn't help that he's easily capable of sneaking up on you due to Cloak and Dagger.
* Riki can use Smoke Screen on top of you as you're reincarnating, making you a sitting duck for your second life. In addition, the blind prevents Wraith King from landing critical hits from Mortal Strike.
* Wraithfire Blast is quite predictable, and players with good reflexes will disjoint it with Tricks of the Trade.
* There is also a chance he will become invisible again as the projectile travels, disjointing it.

* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper

* Living Armor can be used to save a hero from a Relocate gank.

* Clinkz, Sniper, Lone Druid, Troll Warlord, Legion Commander, Wraith King and others are some of the Heroes that bases themselves on attacks with little or no spell power, suffering in the grassy hands of Overgrowth.

* Cold Embrace can render the extra attack speed from Overcharge meaningless.
* Splinter Blast and Winter's Curse are very affective against Io, as it has to stay close to its tethered hero.

* Many physical-only single-target heroes like Lifestealer, Sven, Wraith King, Phantom Assassin etc.

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer

* Diffusal Blade lets Phantom Lancer drain Wraith King's mana, preventing Reincarnation from triggering until he upgrades his talent point at level 20.
Additional:
* Doppelganger disjoints Wraithfire Blast.
* Wraith King is not good at handling illusion-based heroes, as his only disable is single-target.
* Phantom Lancer tends to get Diffusal Blade, leaving Wraith King no mana to reincarnate.

* Heroes with low armor and little mobility, like Huskar, Io, etc. will also have an unfortunate fate.

* Heroes with single-target abilities will be overwhelmed by Lycan and his summons: Wraith King, Bane, Phantom Assassin.

* Strafe and Searing Arrows allow Clinkz to quickly kill Io due to its low armor.

* Broodmother can easily clear Wraith King's skeletons with Spawn Spiderlings and summon spiderlings in their place.
* With Diffusal Blade, Broodmother can prevent Wraith King from reincarnating unless the level 20 talent is chosen.

* Mana Break quickly eats away at Wraith King's small mana pool, preventing Reincarnation from triggering.
* Wraith King has no innate mobility. Even with Blink Dagger, Wraith King is easily kited by Blink.
* Anti-Mage can farm much more quickly than Wraith King, allowing Anti-Mage to overpower Wraith King once a significant farm advantage is established.
Additional:
* Mana Break can prevent Wraith King from reincarnating unless Wraith King picks the level 20 talent that removes the mana cost from Reincarnation.
* With Manta Style, his mana burning will triple because illusions can also use Mana Break.

* Ignite has long duration damage-over-time and prevents Io from healing his Tethered ally.

* Mana Break can deplete Wraith King's mana and prevent him from using Reincarnation.
* Wraith King's lack of area effect spell makes him easily overwhelmed by Beastmaster's summons.

* Lich's Chain Frost forces Io to give up providing buff to his ally with Tether or suffer devastating damage with his tethered ally.
* Lich could easily use Sinister Gaze to disable Io from getting away with Tether or Relocate.

* Lucent Beam can cancel Tether and Relocate.
* Moon Glaives and Eclipse make short work of Io and its tethered ally.

* Wraith King has no form of AoE to clear Chaos Knight's illusions from Phantasm.
* Wraith King is very vulnerable if he reincarnates in the middle of his illusions.

* Weaver can run away after killing Wraith King once thanks to Shukuchi.
* Wraithfire Blast is quite predictable. If Weaver is quick, he will disjoint it with Shukuchi and proceed to chase Wraith King down.
* Shukuchi does have a fade time. They cannot disjoint it if you use it right next to them. They will be stunned and take damage; however they will still become invisible if they used Shukuchi before the stun hits.
* Weaver can easily harass Wraith King out of his lane thanks to his high base damage and Geminate Attack.
* Weaver can burn Wraith King's mana quickly with his Mana Break or Diffusal Blade, until Wraith King picks "No Reincarnation Manacost" talent.
Additional:
* Wraithfire Blast is easy to disjoint with Shukuchi or Time Lapse, and it's the only way to break Weaver's Linken Sphere.
* Wraith King has no other disables and no mobility, allowing Weaver to chase or escape Wraith King as he wishes.
* With the Mana Break talent and Diffusal Blade, Weaver can prevent Reincarnation from triggering until Wraith King has selected the chosen talent.

* Invoker can drain Wraith King's mana with EMP, preventing him from reincarnating.
* Even if Wraith King survives and reincarnates, Invoker still has an arsenal of spells to lockdown Wraith King, including an easily setup Ice Wall.
* Tornado applies an area dispel to clear skeletons.
Additional:
* EMP allows Invoker to burn Wraith King's mana to prevent Reincarnation from triggering (only until Wraith King gets his level 20 talent).
* Ice Wall and Cold Snap are particularly crippling for Wraith King as they allow to kite him very effectively, preventing him from dealing melee attack damage.

* Ice Blast prevents Io from healing the target.
Additional:
* Ice Blast prevents Io from healing an ally with Tether and prevents healing from Overcharge
* Io is a common Mekansm builder which is useless if he is affected by Ice Blast.

* Lightning Storm will usually hit both Io and its tethered target since both will be close enough for the lightning to jump.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to Io and its tethered target.
Additional:
* Lightning Storm will usually hit both Io and his Tethered target since both will be close enough for the lightning to jump. It can then be followed up by Split Earth.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to Io and his Tethered target.

* Glimpse directly negates Relocate.
Additional:
* Disruptor can always Glimpse back Io or his target after he Relocated nearby.
* Even better, thanks to the indicator on the ground, you can even preemptively drop Static Storm and Kinetic Field on the spot they will relocate to.
* Thunder Strike and Glimpse are also good tools to bring back an Io that Tethered away in the fog of war.

* Phantom Strike allows Phantom Assassin jump directly to Io.
* Coup de Grace makes short work of Io's low health and armor.

* Wraith King has a very low mana pool and depends on it to cast Reincarnation. Mana Drain will render him useless.
* Wraith King has very low mobility, making it easy for Lion to disable and harass him.
Additional:
* While not being able to confront Wraith King by himself, Lion's Mana Drain helps in draining Wraith King's mana, preventing him from reincarnating.
* Lion's Earth Spike and Hex provide decent lockdown against Wraith King as well, preventing the latter from benefiting from Vampiric Aura bonuses.

* Dark Pact, if timed correctly, can dispel Wraithfire Blast's stun and slow.
* Since Wraith King has a lot of health and multiple lives, Slark can keep gaining Essence Shift stacks, increasing armor, damage, and attack speed and can beat down Wraith King twice.
* Slark sometimes carries Diffusal Blade to burn mana as an attempt to shut down Reincarnation.
* Because Wraith King has no AoE abilities, Shadow Dance is particularly useful against Wraith King.

* Wraith King has no form of AoE to clear Terrorblade's illusions.
* Terrorblade is a common Manta Style and Diffusal Blade carrier.
* Terrorblade has very high armor, which helps against Wraith King's physical-only damage.
* A reincarnated Wraith King is an ideal target for Sunder if Terrorblade's health is low.

* Sanity's Eclipse does massive damage to Wraith King who naturally has a low mana pool and typically doesn't build items to increase it.
* Wraithfire Blast's slow projectile speed makes it easy to avoid using Astral Imprisonment.

* Heroes who Sniper can kite: Sven, Wraith King, Kunkka, Doom, Tidehunter, Underlord, Troll Warlord, and etc.

* Take Aim and Assassinate allow Sniper to reach Io even if it stays in the backline.

* Grimstroke can catch Io and his ally easily with SoulBind as Io has a tendency to tether himself with an ally frequently.
* Io is highly vulnerable to disables. Hence, Grimstroke's Phantom's Embrace is a great ability to hinder Io's potential.
Additional:
* Soulbind can target both Io and its Tethered ally, allowing Grimstroke and his team to target both with single target spells. Should Io try to Relocate, Phantom's Embrace can stop its channel to prevent escape.

* Quill Spray is very effective against Io, as it has very low armor and has to stay close to the fight to not break its Tether.

* Wraith King's poor mobility makes him vulnerable to Illuminate.
* Blinding Light can reduce his damage output as well as his already abysmal mobility.
* Chakra Magic drains Wraith King's much-needed mana resulting in him not being able to reincarnate

* Wraith King, Medusa, Storm Spirit and other mana dependent heroes will have diminished impact on a fight if they survive Fiend's Grip due to its mana steal.

* Heroes with area dispel can kill multiple skeletons at once: Brewmaster, Oracle.

* Heroes who are reliant on physical damage will be nullified by Decrepify: Riki, Wraith King, Juggernaut.

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer

* Squishy heroes (Io, Crystal Maiden, Lina...), as Earth Spirit can deal tons of damage with Magnetize.

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer

* Heroes who can delivers a big chunk of damage in few hits will find themselves struggle against Templar Assassin's Refraction: Sven, Phantom Assassin, Ursa, Wraith King, Lifestealer

* Heroes with summons and illusions such as Broodmother and Naga Siren, are ill-suited for Wraith King to fight, as he has no source of waveclear.

* Heroes with area dispel can kill multiple skeletons at once: Brewmaster, Oracle.

* Heroes who rely on physical damage will suffer from Laser: Phantom Assassin, Wraith King, Huskar.

* Heroes that lack burst damage will have a difficult time taking down Monkey King, and fare badly against Jingu Mastery: Legion Commander, Lifestealer, Weaver, Wraith King

Additional:
* Wraith King has no ability to destroy trees from Tree Dance.
* Monkey King tends to get Diffusal Blade, leaving Wraith King no mana to reincarnate.
* A reincarnated Wraith King is an ideal target for Wukong's Command.

* Wraithfire Blast is quite predictable, and players with good reflexes will disjoint it with Blade Fury.
* Omnislash with Diffusal Blade & Aghanim's Scepter can prevent Wraith King from reincarnating unless he picks the level 20 talent that removes the mana cost from Reincarnation.

* Charge of Darkness can be used to escape or counter-initiate against a Relocate gank.
* Greater Bash and Nether Strike is devastating due to Io's low armor, and can even knock it away from tethered target.